Acetylcholinesterase (AChE) is an enzyme that catabolises
ACh. Compounds that block AChE (anti-
AChE) will augment synaptic ACh and therefore enhance
nAChR signalling. AChE blockade also enhances
signalling at muscarinic ACh receptors
(mAChRs). Eight in vitro studies demonstrated that
mAChR agonists such as ACh, pilocarpine, carbachol,
and oxotremorine reliably augmented endocannabinoid
release and consequential CB1 signalling (see review
in ). Animal studies have shown that pilocarpine and
oxotremorine increased the effects of THC [10, 34].
Based on the evidence that nAChR and mAChR agonists
augment the effects of cannabinoids, we would
predict that anti-AChE compounds do the same. But
they apparently do not. In animals studies, physostigmine
(anti-AChE as well as a mixed nAChR and
mAChR agonist and a nAChR allosteric agonist) enigmatically
decreased THC discrimination , THC
sedation , and THC memory deficits [37, 38]. In
one clinical report, physostigmine decreased the THC
„high,” tachycardia, red eye, and dry mouth, although
the patient experienced greater sedation .
Calamus root (Acorus calamus) contains beta-asarone,
an anti-AChE compound . Reports in the grey
literature describe calamus diminishing cannabimimetic
effects (e.g., ). Adding a „pinch” of dried,
powdered calamus per pipe bowl of cannabis provides
„mental clarity and memory enhancement” [42, 43].
Adding calamus to cannabis dates to ancient India;
according to Ayurvedic medical texts, calamus „balances”
and „neutralizes the toxic side effects” of cannabis
. The Ayurvedic usage of calamus as a sedative
contradicts its traditional use by North American
Cree Indians as a stimulant; the discrepancy may be
due to pharmacological differences between Asian and
American A. calamus .
Relazione entro Calamo Aromatico e Cannabis, a qualcuno potrà interessare.
Sembra che da milleni il potere curativo del Calamo possa giovare alla perdita di memoria e lucidità dovuta alla Cannabis, agendo inibendo l'acetilcolina (neurotrasmettitore della memoria).